Free delivery on all NHS prescriptions — order now
- Home
- Travel Health
- Jet Lag
- Circadin (Melatonin)
Circadin (Melatonin)
Images for illustrative purposes only
Circadin is an effective prolonged-release melatonin tablet prescribed to treat insomnia and jet lag in adults, helping you fall asleep faster and improving your overall sleep quality by mimicking the body's natural sleep hormone.
- Contains 2mg melatonin as the active ingredient
- Clinically proven to reduce sleep latency and improve morning alertness
- Non-addictive formula available via online prescription
- Discreet, fast delivery from our UK-registered pharmacy
More information
"Circadin is primarily prescribed for the short-term treatment of primary insomnia in patients aged 55 and over, though it is also widely used off-label or via private consultation for jet lag and circadian rhythm sleep disorders in younger adults. This 2mg prolonged-release formulation is designed to release melatonin gradually throughout the night, mimicking the body's endogenous secretion patterns to help you stay asleep longer and wake up feeling more refreshed." — Rachael Clarke MRCPharm MFRPSI FRSPH (GPHC Number: 2061366)
You can buy Circadin online safely through our online consultation process, where a registered prescriber reviews your medical history to ensure melatonin tablets are appropriate for you. Once approved, your medication is dispensed and shipped directly from our UK-based pharmacy (GPHC Number: 9011560) in discreet packaging to ensure your privacy.
We provide competitive pricing for Circadin 2mg tablets, offering value alongside our professional pharmaceutical service. Prices vary depending on the quantity of tablets you are trying to buy.
We offer several delivery options to suit your schedule, including tracked next-day delivery and standard shipping across the UK. All orders are sent in plain, unbranded packaging, and if your consultation is approved before our daily cutoff time, we aim to dispatch your melatonin medication the same day.
Circadin is a prescription medication used to treat primary insomnia, a condition characterised by poor sleep quality or difficulty falling asleep. While often used for jet lag in the UK, its primary role is to supplement the natural melatonin hormone levels, which may decline with age or be disrupted by travel and shift work.
The active ingredient in this medication is melatonin, with each tablet containing 2mg in a prolonged-release matrix. Excipients include ammonio methacrylate copolymer type B, calcium hydrogen phosphate dihydrate, and lactose monohydrate, which facilitate the slow release of the hormone into your system.
Many patients report that melatonin 2mg helps them establish a more consistent sleep routine without the "hangover effect" of stronger sleeping pills. According to NHS guidelines and patient feedback, users often find it particularly helpful for jet lag recovery and improving sleep latency (the time it takes to fall asleep).
Before you order melatonin online, it is vital to read the Patient Information Leaflet (PIL) provided with your medication. You can also access a digital version on the electronic Medicines Compendium (eMC) to understand the full safety profile and usage instructions for Circadin melatonin.
Melatonin works by binding to receptors in the brain's suprachiasmatic nucleus, signalling to your body that it is time to sleep. Because Circadin is a prolonged-release tablet, it maintains a steady level of the sleep hormone in your blood for several hours, more closely resembling the natural melatonin production of a healthy sleep cycle.
You should take one Circadin 2mg tablet once daily, ideally 1 to 2 hours before your intended bedtime. The tablet must be swallowed whole to preserve its prolonged-release properties. Do not crush, chew, or break the tablet, as this will cause all the melatonin to be released at once.
The standard melatonin dosage for adults is 2mg per day, taken after food. While some people ask, "Can I take 10mg melatonin?" you should never exceed the dose prescribed by your healthcare professional, as higher doses can increase the risk of side effects like vivid dreams or morning drowsiness.
Most people tolerate melatonin tablets well, but some may experience side effects such as irritability, nervousness, or unusual dreams. Common melatonin negative effects include:
- Drowsiness or "heavy-headedness" the next morning.
- Headaches or dizziness.
- Abdominal pain or dry mouth.
Melatonin is a hormone and should be used with caution if you have autoimmune diseases or are taking certain medications like fluvoxamine or benzodiazepines. You should avoid alcohol while taking this medication, and it is generally not recommended for use during pregnancy or breastfeeding without explicit medical advice.
| Medication | Type | Best For | Prescription Status |
|---|---|---|---|
| Circadin (Melatonin) | Hormone (Natural) | Insomnia (55+), Jet Lag | Prescription Only (UK) |
| Zopiclone | Sedative (Z-drug) | Severe Insomnia (Short-term) | Prescription Only |
| Nytol (Diphenhydramine) | Antihistamine | Occasional sleeplessness | Over-the-counter |
Is melatonin legal in the UK?
Yes, melatonin is legal in the UK, but it is classified as a prescription-only medication (POM). You cannot buy melatonin over-the-counter in UK high street shops. It must be dispensed by a registered pharmacy following a clinical consultation.
How long does melatonin take to work?
Typically, melatonin takes 1 to 2 hours to work. Because Circadin is a prolonged-release tablet, you should take it consistently at the same time each evening to help regulate your circadian rhythm effectively.
Why is melatonin banned in the UK?
Melatonin is not banned in the UK, but it is regulated differently than in the US. The MHRA treats it as a medicinal product rather than a food supplement to ensure quality control and that patients receive proper medical screening before use.
The information provided on this page is for general informational purposes only and should not replace seeking advice from a medical professional for personalised treatment. Always consult with your GP or a qualified healthcare provider before starting any new melatonin medication.
At Mail My Meds, our content is regularly reviewed by our team of medical experts and pharmacists to ensure it remains up to date, accurate, and aligned with the latest NICE and BNF guidelines. We prioritise your health and safety by providing evidence-based information on all our sleep tablets and treatments.

