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Differin Cream
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Differin Cream is a highly effective topical retinoid treatment containing the active ingredient adapalene 0.1% which is clinically proven to treat mild to moderate acne by regulating skin cell turnover and preventing the formation of new blemishes.
- Contains 0.1% adapalene to target acne at the source
- Effectively clears blackheads, whiteheads and blocked follicles
- Calms redness and swelling associated with acne vulgaris
- Ideally suited for those with dry or sensitive skin types
More information
"Differin Cream is a third-generation topical retinoid typically prescribed for the treatment of acne vulgaris in patients aged 12 and over. It is particularly effective for targeting comedones (blackheads and whiteheads) as well as inflammatory papules and pustules on the face, chest or back. Because it is formulated as a cream, it is often preferred by patients with drier or more sensitive skin compared to gel alternatives." - Rachael Clarke MRCPharm MFRPSI FRSPH (GPHC Number: 2061366)
You can buy Differin Cream safely through Mail My Meds by completing a short online consultation which is reviewed by a UK registered prescriber. Once your consultation is approved, your medication is shipped discreetly from our pharmacy (GPHC Number: 9011560) directly to your home. This process ensures you receive the correct treatment for your skin type without needing an in-person GP appointment.
The price of Differin Cream depends on the volume of medication required for your specific treatment plan. While private prescription costs may vary compared to the standard NHS levy, purchasing online often provides a competitive and transparent pricing structure. You can view the current price for your selection during the checkout process.
We provide a range of delivery services to ensure your acne treatment arrives when you need it. Options include tracked delivery and expedited shipping, all sent in plain, discreet packaging to maintain your privacy. Delivery times and costs will be displayed clearly before you complete your order.
Differin Cream is a medicated topical treatment used to manage mild to moderate acne by preventing the blockage of pores. It belongs to a class of drugs known as retinoids, which are derived from Vitamin A and are essential for maintaining healthy skin texture. By reducing the number and severity of acne spots, it helps patients achieve clearer skin and promotes the healing of existing pimples.
The active ingredient in this treatment is adapalene, provided at a concentration of 0.1% w/w. Adapalene is a stable retinoid-like compound that specifically targets the processes in the skin that lead to acne, such as abnormal keratinisation and inflammation. Other ingredients include glycerol, natural squalane and carbomer 934P, which help the cream remain gentle on the skin barrier.
Many users report a significant reduction in blackheads and inflammatory spots within the first 4 to 8 weeks of consistent use. While some experience an initial "purge" where acne seems to briefly worsen, long-term studies show that up to 87% of patients see a marked improvement in their skin condition after a full 12-week course. Patients with dry skin frequently comment on the cream's moisturising texture compared to thinner gels.
The Patient Information Leaflet (PIL) is included with every tube of Differin and contains vital data regarding its safe use. You should read this document thoroughly before starting your treatment to understand the full list of ingredients and potential interactions. An electronic version is also available via the Electronic Medicines Compendium (emc) website.
Differin works by normalising the growth of keratinocytes in the skin follicles to prevent pores from becoming clogged with oil and dead skin cells. This comedolytic action stops blackheads and whiteheads from forming at the very beginning of the acne cycle. Furthermore, its anti-inflammatory properties help to soothe the redness and swelling that occur during an active breakout.
You should apply Differin Cream once daily in the evening to the entire area affected by acne, rather than using it as a spot treatment. Before application, wash the skin with a mild, non-medicated cleanser and ensure it is completely dry. Use your fingertips to apply a thin film across the face, chest or back, avoiding the eyes, lips and nostrils.
The recommended dosage is a single daily application, usually before retiring to bed. Using more than the prescribed amount will not clear your acne faster and is likely to cause significant skin irritation and peeling. Consistency is key, and most prescribers recommend continuing the treatment for at least 12 weeks to see the full therapeutic benefit.
Common side effects of Differin include dry skin, redness and a mild burning or stinging sensation during the first few weeks of use. These symptoms usually subside as your skin adapts to the retinoid. If you experience severe blistering, swelling of the face or an intense allergic reaction, you must stop using the product and seek medical attention immediately.
Common Side Effects (Up to 1 in 10 people)
- Skin dryness or peeling
- Mild burning or stinging
- Skin redness (erythema)
- Initial worsening of acne (purging)
You must not use Differin if you are pregnant or planning to become pregnant, as retinoids can potentially affect foetal development. Avoid using the cream on skin with cuts, scrapes or eczema, and limit your exposure to strong sunlight and UV lamps during treatment. It is recommended to use a high-factor sunscreen (SPF 30 or above) daily while using this medication.
| Feature | Differin (Adapalene) | Benzoyl Peroxide | Tretinoin |
|---|---|---|---|
| Mechanism | Regulates cell turnover | Kills bacteria | Accelerates cell turnover |
| Irritation Risk | Moderate (Lower than Tretinoin) | Moderate (Can bleach fabric) | Higher |
| Best For | Blackheads & whiteheads | Inflammatory spots | Severe acne & anti-ageing |
Can I use moisturiser with Differin Cream?
Yes, you can use a non-comedogenic (oil-free) moisturiser to help manage any dryness or peeling caused by the treatment. It is often helpful to apply your moisturiser after the Differin has been fully absorbed into the skin.
How long does it take for Differin to work?
Most patients start to see a visible improvement in their skin within 4 to 8 weeks of daily use. However, you should continue the treatment for the full 12 weeks as prescribed to achieve the best possible results.
Can I use Differin while breastfeeding?
Differin can be used during breastfeeding, but it should not be applied to the chest area to avoid any accidental contact with the infant. Always consult your prescriber before starting a new medication while nursing.
The information provided here is for general informational purposes only and should not replace seeking advice from a medical professional. Always consult with a doctor or pharmacist for personalised medical advice regarding your skin condition and treatment options.
Our content is regularly reviewed by our team of medical experts and registered pharmacists to ensure it remains up to date and accurate. We strive to provide reliable information that follows the latest UK clinical guidelines for acne management.
