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Prochlorperazine (Prochlorperazine Maleate)
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Prochlorperazine is an effective anti-sickness medication used to treat nausea, vomiting, and balance disorders like vertigo, containing the active ingredient Prochlorperazine Maleate which belongs to the phenothiazine class of medicines.
- Helps to reduce feelings of nausea and vomiting within 30 to 60 minutes
- Effectively manages symptoms of vertigo, dizziness, and Ménière’s disease
- Frequently prescribed to alleviate sickness associated with migraine headaches
- Available in standard oral tablets and convenient buccal (dissolving) versions
More information
"Prochlorperazine is a clinically proven antiemetic typically prescribed for the management of severe nausea and vomiting, as well as vestibular disorders such as vertigo and Ménière's disease. By targeting dopamine receptors in the brain, it effectively interrupts the signals that trigger the vomiting reflex, providing essential relief for patients struggling with balance issues or migraine-related sickness." - Rachael Clarke MRCPharm MFRPSI FRSPH (GPHC Number: 2061366)
You can buy Prochlorperazine through Mail My Meds by completing a convenient online consultation with a registered prescriber to ensure the treatment is suitable for your health needs. Once your consultation is approved, your medication is shipped discreetly from our pharmacy (GPHC Number: 9011560) directly to your home. This process provides a secure and professional way to manage your prescriptions without the need for a face-to-face GP appointment.
The price of Prochlorperazine varies depending on whether you are fulfilling a standard NHS prescription or opting for a private prescription service. At Mail My Meds, we aim to provide competitive pricing for all our medications, ensuring you receive affordable care alongside our professional pharmacy services. You can view the current costs during the checkout process after your consultation is finalised.
We offer a range of discreet delivery options to ensure your treatment reaches you quickly and safely across the UK. After your prescription is issued by our clinical team, your order is packaged securely to maintain privacy. You can choose from various postage speeds at the point of purchase to suit your schedule and urgency.
Prochlorperazine is a medication primarily used to prevent and treat nausea and vomiting caused by various conditions, including migraines, inner ear problems, and post-operative recovery. It belongs to the phenothiazine group of medicines, which have been used for decades in the UK to manage vestibular symptoms like dizziness and the spinning sensations associated with vertigo or Ménière's disease.
The active ingredient in this treatment is Prochlorperazine Maleate, a potent dopamine antagonist. Each tablet also contains inactive excipients which may include lactose or sucrose, depending on the specific manufacturer, so it is important to check the ingredients if you have known sugar intolerances.
Many users report that Prochlorperazine provides rapid relief from the debilitating effects of nausea and vertigo, often allowing them to return to daily activities sooner. While most patients tolerate the medication well, some individuals mention feeling drowsy or experiencing a dry mouth as the treatment takes effect. Experiences can vary based on the condition being treated, such as acute migraine sickness versus long-term balance issues.
The Patient Information Leaflet (PIL) provides essential technical details and safety instructions for your specific brand of medication. You should always read the PIL included in your medicine pack before starting treatment. It contains a comprehensive list of ingredients, full side effect profiles, and storage requirements.
Prochlorperazine works by blocking the action of dopamine in the brain, specifically in the area known as the vomiting centre. By inhibiting these chemical signals, the medication prevents the brain from triggering the physical sensation of nausea and the urge to vomit. For vertigo, it helps to quieten the signals from the inner ear that cause dizziness and loss of balance.
You should use Prochlorperazine exactly as directed by your prescriber, following the specific instructions for the type of tablet you have been issued. Standard tablets are usually swallowed whole with water, whereas buccal tablets are placed high up between your upper lip and gum to dissolve slowly. Do not crush or chew buccal tablets, as they are designed to be absorbed through the lining of your mouth.
The typical dosage of Prochlorperazine depends on the condition being treated and the age of the patient. For most adults, the following table outlines common regimens:
| Condition | Common Adult Dosage |
|---|---|
| Nausea and Vomiting | 5mg to 10mg two or three times daily |
| Vertigo/Ménière’s | 5mg three times daily (can be increased if needed) |
| Migraine Sickness | 5mg to 10mg at the onset of symptoms |
Common side effects of Prochlorperazine may include drowsiness, dizziness, and a dry mouth, though these are often mild and temporary. Some users may also experience blurred vision or a slight drop in blood pressure when standing up. While rare, serious side effects can occur, and you should contact a healthcare professional immediately if you notice unusual muscle movements, tremors, or signs of an allergic reaction.
Prochlorperazine may not be suitable for everyone, particularly those with Parkinson’s disease, liver problems, or a history of blood clots. It can cause increased sensitivity to sunlight, so you should avoid direct sun exposure and wear high-factor sunscreen while taking this medication. Alcohol should be avoided during treatment as it can significantly increase drowsiness and the risk of breathing difficulties.
Prochlorperazine is often preferred for vertigo and inner ear issues compared to other antiemetics like Cyclizine or Ondansetron. While Cyclizine is frequently used for motion sickness, Prochlorperazine's specific action on dopamine receptors makes it highly effective for migraine-associated nausea. Unlike some older antihistamines, it is generally considered less sedating, though individual reactions vary.
Can I take Prochlorperazine while pregnant?
Prochlorperazine is sometimes prescribed for severe pregnancy sickness (hyperemesis gravidarum), but it should only be used under the direct supervision of a doctor or midwife.
How long does it take for Prochlorperazine to work?
Most patients begin to feel the effects of the medication within 30 to 60 minutes after taking a dose.
Will Prochlorperazine make me sleepy?
Drowsiness is a known side effect. You should not drive or operate machinery until you know how the medication affects you.
The information provided is for general informational purposes only and shouldn't replace seeking seeing a medical professional for personalised advice.
Our content is regularly reviewed by our team of medical experts to ensure it is up to date and accurate.

