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Silkis Ointment
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Silkis Ointment is a targeted topical medication containing the active ingredient calcitriol used to manage mild to moderate plaque psoriasis by slowing the excessive production of skin cells.
- Effective topical treatment for mild to moderate plaque psoriasis
- Contains the active ingredient calcitriol, a vitamin D derivative
- Helps to regulate skin cell production and reduce inflammation
- Non-steroid formula suitable for sensitive areas like skin folds
More information
"Silkis Ointment is a clinically proven non-steroidal treatment typically prescribed for adults with mild to moderate plaque psoriasis. It works effectively to soothe scaly patches and redness by returning skin cell growth to a natural rhythm. This treatment is often preferred for its suitability on sensitive areas where traditional steroid creams might be too potent."
- Rachael Clarke MRCPharm MFRPSI FRSPH (GPHC Number: 2061366)
You can purchase Silkis Ointment through Mail my Meds by completing a simple online consultation with one of our UK registered prescribers. Once your consultation is approved, your medication is dispensed and shipped directly from our registered pharmacy (GPHC Number: 9011560) in discreet packaging. This process ensures you receive the correct treatment safely and conveniently without needing to visit a GP in person.
The price of Silkis Ointment at Mail my Meds is competitive and includes the cost of your online clinical consultation and private prescription. Choosing an online pharmacy for your psoriasis care often provides a more cost-effective and time-saving alternative to traditional routes. You can view the current pricing at the top of this product page before starting your order.
We offer a range of flexible delivery options to ensure your Silkis Ointment reaches you quickly and securely across the UK. All orders are sent in plain, unbranded packaging to maintain your privacy. Once your prescription is approved by our medical team, you will receive tracking information so you can monitor your delivery directly to your door.
Silkis is a topical ointment used to treat plaque psoriasis, a chronic condition characterised by red, scaly patches of skin known as plaques. Unlike many other treatments, it is a non-steroidal vitamin D analogue. It is specifically indicated for patients where the affected area covers no more than one-third of the body surface.
The active substance in this medication is calcitriol, which is present at a concentration of 3 micrograms per gram of ointment. Calcitriol is a naturally occurring form of Vitamin D that plays a vital role in skin health. The ointment base consists of liquid paraffin, white soft paraffin, and alpha-tocopherol to help moisturise and protect the skin barrier during treatment.
Many patients report that Silkis Ointment is highly effective for managing flare-ups in sensitive areas like the groin or skin folds where other treatments may cause irritation. Users often notice a visible reduction in scaling and redness within the first two to four weeks of consistent application. Because it is a grease-based ointment, it is also praised for its ability to soften dry, stubborn plaques.
You should always read the Patient Information Leaflet (PIL) provided with your medication for a full list of ingredients and safety advice. The PIL contains essential details on how to store your ointment and what to do if you experience an adverse reaction. If you have misplaced your leaflet, you can request a digital copy from our pharmacy team or view it on the electronic Medicines Compendium (eMC) website.
Silkis Ointment works by binding to vitamin D receptors in the skin cells, specifically targeting keratinocytes to slow down their over-production. In a healthy cycle, skin cells take weeks to mature. In psoriasis, this happens in days, leading to plaque buildup. Calcitriol normalises this process, reducing the thickness of the plaques and calming the associated inflammation and redness.
To use the treatment correctly, apply a thin layer to the affected areas of skin twice daily, typically once in the morning and once in the evening. Ensure the skin is clean and dry before application. It is important to rub the ointment in gently until it is absorbed. Always wash your hands immediately after use to prevent the medication from spreading to healthy skin or sensitive areas like the eyes.
The standard dosage for adults is two applications per day, and you should not exceed a maximum of 30 grams of ointment daily. Over-application will not clear the psoriasis faster but may increase the risk of side effects related to calcium levels in the body. Most clinical improvements are observed after 4 to 8 weeks of continuous use as prescribed by your clinician.
Common side effects of Silkis Ointment are generally mild and localised to the site of application. These may include:
- Itching or skin discomfort
- Minor skin redness (erythema)
- Dry or peeling skin
- Burning or stinging sensations
Rare but serious side effects can involve changes in calcium metabolism. If you experience excessive thirst, frequent urination, or nausea, contact a healthcare professional immediately.
Do not apply Silkis Ointment to the face, eyes, or lips, as these areas are highly prone to irritation. You must not use this medication if you have high blood calcium levels or are taking other medications that affect calcium metabolism, such as thiazide diuretics. Do not cover the treated area with bandages or "occlusive" dressings unless specifically told to do so by your doctor, as this can increase absorption to unsafe levels.
Silkis is often compared to other Vitamin D analogues like Dovonex (calcipotriol) or steroid-based treatments like Betnovate. The following table highlights the key differences:
| Feature | Silkis (Calcitriol) | Steroid Creams |
|---|---|---|
| Type | Vitamin D Analogue | Corticosteroid |
| Usage Period | Suitable for longer term | Usually short-term only |
| Skin Thinning | No risk | Risk with prolonged use |
| Sensitivity | Gentle on skin folds | Can be too potent for folds |
Can I use Silkis Ointment on my face?
No, you should avoid applying Silkis to the face as it can cause significant irritation and redness in this sensitive area.
Is Silkis Ointment a steroid?
No, Silkis is a non-steroidal treatment. It uses a vitamin D derivative called calcitriol to manage skin cell growth without the risks associated with long-term steroid use.
How long does one tube of Silkis last?
This depends on the size of the area you are treating, but you must not use more than 30g per day or 210g per week to ensure your calcium levels remain stable.
The information provided on this page is for general informational purposes only and should not replace seeking advice from a medical professional. Always consult with a GP or pharmacist for personalised medical guidance regarding your specific condition and treatment plan.
Our content is regularly reviewed by our team of medical experts and registered pharmacists to ensure it remains up to date, accurate, and aligned with current UK clinical guidelines.
