Free delivery on all NHS prescriptions — order now
- Home
- Chronic Conditions
- High Cholesterol
- Simvastatin
Simvastatin
Images for illustrative purposes only
Simvastatin is a widely prescribed statin medication used to lower high cholesterol and triglycerides in the blood while helping to prevent cardiovascular disease and strokes. This treatment contains the active ingredient simvastatin, which works by reducing the amount of cholesterol produced by the liver, particularly when combined with a heart-healthy diet and regular exercise.
- Effective at lowering "bad" LDL cholesterol and triglycerides
- Supports the reduction of risk for heart attacks and strokes
- Active ingredient Simvastatin belongs to the statin family
- Convenient online consultation with a UK-registered prescriber
More information
"Simvastatin is a highly effective lipid-lowering medication typically prescribed for patients with primary hypercholesterolaemia or those at high risk of coronary heart disease due to conditions like diabetes or a history of stroke. By regulating the production of fatty substances in the blood, it plays a vital role in long-term cardiovascular health and the prevention of major cardiac events." - Rachael Clarke MRCPharm MFRPSI FRSPH (GPHC Number: 2061366)
You can buy Simvastatin through the Mail My Meds online platform by completing a simple and discreet health consultation. If your consultation is approved by one of our registered prescribers, your medication will be shipped directly from our pharmacy (GPHC Number: 9011560) to your home in plain packaging. This process ensures you receive genuine UK-licensed medication without needing to visit a GP in person for repeat supplies.
The price of Simvastatin varies depending on the strength and quantity required for your specific treatment plan. At Mail My Meds, we aim to provide competitive pricing for both NHS and private prescriptions. You can view the current costs during the selection process before completing your order.
We offer several reliable delivery options to ensure your medication arrives quickly and securely. Once your order is approved, you can choose from various tracked shipping methods. All treatments are sent in discreet, unbranded packaging to maintain your privacy.
Simvastatin is a prescription-only medicine used to treat high blood cholesterol and prevent cardiovascular issues. It is primarily used for hypercholesterolaemia, a condition where there is too much "bad" cholesterol (LDL) in the blood. In the UK, it is often prescribed to those with a 10% or higher risk of developing cardiovascular disease over the next decade.
The active ingredient in this medication is simvastatin, which belongs to the class of drugs known as HMG-CoA reductase inhibitors. These tablets may also contain inactive ingredients such as lactose, microcrystalline cellulose, and starch, which help form the tablet and assist with its absorption in the body.
Many users find Simvastatin easy to incorporate into their routine as it only requires a single dose taken in the evening. Most people tolerate the medication well, though some individuals report mild initial side effects like digestive upset which often settle over time. Patient satisfaction remains high due to its proven track record in lowering lipid levels effectively.
The Patient Information Leaflet (PIL) is included in every box of medication and provides detailed data on how to take the treatment safely. It is essential to read this document before starting your course. You can also access digital versions of the PIL through our website or the electronic Medicines Compendium (eMC).
Simvastatin works by blocking an enzyme in the liver called HMG-CoA reductase, which is responsible for the production of cholesterol. By inhibiting this enzyme, the liver produces less cholesterol and increases its ability to remove existing "bad" cholesterol from the blood. This helps prevent the buildup of fatty plaques in the arteries, a process known as atherosclerosis.
You should take Simvastatin exactly as directed by your healthcare provider, usually once daily in the evening. Taking the medication at night is recommended because the body’s cholesterol production peaks while you sleep. You can take the tablets with or without food, but they should be swallowed whole with a glass of water.
The dosage of Simvastatin is tailored to your individual health needs and cholesterol levels. Common daily doses range from 10mg to 40mg, though some patients may require 80mg under specialist supervision. Below is a general guide to typical dosing:
| Condition | Typical Starting Dose |
|---|---|
| High Cholesterol | 10mg or 20mg once daily |
| High Cardiovascular Risk | 20mg or 40mg once daily |
| Maximum Dose | 80mg once daily (specialist only) |
While most people do not experience significant problems, some side effects can occur during treatment. Common side effects include digestive issues like constipation, wind, or nausea, as well as headaches. Rare but serious side effects include unexplained muscle pain or weakness, which should be reported to a doctor immediately.
You should not take Simvastatin if you are pregnant, planning to become pregnant, or breastfeeding. It is also important to avoid grapefruit juice while taking this medication as it can significantly increase the levels of the drug in your blood. Inform your prescriber if you have a history of liver disease or if you drink large amounts of alcohol.
Simvastatin is one of several statins available in the UK, often compared with Atorvastatin or Rosuvastatin. While all statins lower cholesterol, Simvastatin is typically considered a "medium intensity" statin at standard doses. It is often chosen for its cost-effectiveness and long-standing clinical history, whereas Atorvastatin may be preferred for patients requiring more intensive lipid reduction.
Can I drink alcohol with Simvastatin?
Moderate alcohol consumption is generally acceptable, but heavy drinking increases the risk of liver problems and muscle side effects. It is best to discuss your alcohol intake with your prescriber during the consultation.
Why must I avoid grapefruit juice?
Grapefruit contains chemicals that interfere with the way your body breaks down Simvastatin, which can lead to dangerously high levels of the medicine in your system. This increases the risk of serious muscle damage.
How long do I need to take Simvastatin?
Treatment for high cholesterol is usually lifelong. If you stop taking the medication, your cholesterol levels are likely to return to their previous high levels, increasing your cardiovascular risk.
The information provided here is for general informational purposes only and should not replace seeking advice from a medical professional for personalised care. Always consult with your doctor or pharmacist before starting a new medication to ensure it is safe for your specific health circumstances.
Our content is regularly reviewed by our team of medical experts to ensure it remains up to date and accurate. We follow strict editorial guidelines to provide reliable health information that aligns with the latest UK clinical standards.

